城西大学 薬学部 皮膚生理学研究室

english

研究業績

 

2020年

  • Shota Sakai, Asami Makino, Akihito Nishi, Takeshi Ichikawa, Tadashi Yamashita, Makoto Taniguchi, Yoshihiro Tokudome, Yoshio Hirabayashi, Masashi Akiyama, Debra Crumrine, Yoshikazu Uchida, Peter M Elias, Tetsuya Tsuchida, Sumiko Hamanaka,
    Pathogenic and compensatory mechanisms in epidermis of sphingomyelin synthase 2-deficient mice,
    Skin Pharmacology and Physiology, 2020, accepted
  • Moe Otsuka, Tsuyoshi Tamane and Yoshihiro Tokudome *,
    Effect of lactic fermentation products on human epidermal cell differentiation, ceramide content, and amino acid production,
    Skin Pharmacology and Physiology, 2020, accepted
  • Erika Saito, Madoka Kage and Yoshihiro Tokudome *,
    Enhancement of cornified envelope-related gene and protein expression by carba cyclic phosphatidic acid in normal human epidermal keratinocytes,
    Biological and Pharmaceutical Bulletin, 2020, accepted
  • Miki Shigefuji and Yoshihiro Tokudome *,
    Nanoparticulation of hyaluronic acid: A new skin penetration enhancing polyion complex formulation: mechanism and future potential,
    Materialia, 14, 100879, 2020, https://doi.org/10.1016/j.mtla.2020.100879
  • Yoshihiro Tokudome *, Tsuyoshi Hoshi, Sayaka Mori, Ichiro Hijikuro,
    Synthesis of resorcinol derivatives and their effects on melanin production,
    Cosmetics, 7, 33, 2020, doi:10.3390/cosmetics7030055
  • Yoshihiro Tokudome *, Haruna Tsukiji
    Mannosylerythritol lipid B enhances the skin permeability of the water-soluble compound calcein via OH stretching vibration changes,
    Colloids and Interfaces, 4, 10, 2020, doi:10.3390/colloids4010010
  • 徳留 嘉寛, 玉根 強志,
    皮膚用保湿機能剤,
    特開2020-100574
           

2019年

  • Yoshihiro Tokudome *,
    Improvement of skin barrier function with various physiologically active substances,
    YAKUGAKU ZASSHI, 139, 1549-1551, 2019.

2018年

  • Yoshihiro Tokudome*, Tatsuya Komi, Ami Omata, Marie Sekita,
    A new strategy for the passive skin delivery of nanoparticulate, high molecular weight hyaluronic acid prepared by a polyion complex method,
    Scientific Reports, 8, 2336, 2018, doi: 10.1038/s41598-018-20805-3.
  • Koji Nomoto, Yurina Itaya, Ken Watanabe, Tadashi Yamashita, Toshiro Okazaki, Yoshihiro Tokudome *,
    Epidermal permeability barrier function and sphingolipid content in the skin of sphingomyelin synthase 2 deficient mice,
    Experimental Dermatology, 27, 827, 2018, DOI: 10.1111/exd.13497.
  • Mariko Yokota, Shoichi Yahagi, Yoshihiro Tokudome, Hitoshi Masaki,
    Chimyl alcohol suppresses PGE2 synthesis by human epidermal keratinocytes through the activation of PPAR-γ,
    Journal of Oleo Science, 67, 455-462, 2018. doi: 10.5650/jos.ess17157.
  • Yoshihiro Tokudome*,
    Influence of oral administration of lactic acid bacteria metabolites on skin barrier function and water content in a murine model of atopic dermatitis,
    Nutrients, article no. 1858, 2018, https://www.mdpi.com/2072-6643/10/12/1858
  • 森 俊裕,徳留 嘉寛,
    ケラチン5遺伝子発現促進剤、ケラチン10遺伝子発現促進剤、ロリクリン遺伝子発現促進剤、及びトランスグルタミナーゼ遺伝子発現促進剤,
    特開2018-203676
  • 森 俊裕,徳留 嘉寛,
    Nrf2遺伝子発現促進剤、カタラーゼ遺伝子発現促進剤、及びグルタチオンペルオキシダーゼ遺伝子発現促進剤,
    特開2018-203675

2017年

  • Takashi Koikeda, Yoshihiro Tokudome, Musashi Okayasu, Yuki Kobayashi, Kohei Kuroda, Junko Yamakawa, Kiyosato Niu, Kou Masuda, Masami Saito,
    Effects of peach (Prunus persica)-derived glucosylceramide on the human skin.
    Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, 2017, 17, 56-70
  • Mami Yokota, Marie Sekita, Yuri Okano, Hitoshi Masaki, Masayoshi Takeuchi, Yoshihiro Tokudome*,
    Glyceraldehyde-derived advanced glycation end products accumulate faster than Nε-(carboxymethyl) lysine,
    Annals of Dermatology, 29, 508- 511, 2017.
  • Mami Yokota, Hitoshi Masaki, Yuri Okano, Yoshihiro Tokudome*,
    Effect of glycation focusing on the process of epidermal lipid synthesis in a reconstructed skin model and membrane fluidity of stratum corneum lipids,
    Dermato-Endocrinology, e1338992, 2017.
    https://doi.org/10.1080/19381980.2017.1338992
  • Yoshihiro Tokudome*, Yoshimi Takahashi,
    Antioxidants inhibit subsequent lipid production via sebaceous gland cell differentiation,
    Journal of Dermatology and Cosmetology, 1, Article No-00015, 2017.
  • Yoshihiro Tokudome*, Noriomi Masutani, Shohei Uchino, Hisano Fukai,
    Recovery effects of oral administration of glucosylceramide and beet extract on skin barrier destruction by UVB in hairless mice,
    Nutrients, 9, 1178, 2017.
  • 徳留 嘉寛,
    ヒアルロナンを含む複合粒子を含有する乳化組成物,
    特開2017-066046

2016年

  • Madoka Kage, Yoshihiro Tokudome*,
    Hyaluronan tetrasaccharide stimulates ceramide production through upregulated mRNA expression of ceramide synthesis-associated enzymes,
    Archives of Dermatological Research, 308, 95-101, 2016.
  • Yurina Itaya, Yoshihiro Tokudome*,
    Upregulation of gene expression levels of ceramide metabolic enzymes after application of sphingomyelin-based liposomes to a three-dimensional cultured human epidermis model,
    Biochemical and Biophysical Research Communications, 473, 114-117, 2016.
  • Mami Yokota, Yoshihiro Tokudome*,
    The effects of glycation on the composition, metabolism and barrier function of epidermal lipids,
    Skin Pharmacology and Physiology, 29, 231-242, 2016.
  • Madoka Kage, Yoshihiro Tokudome*,
    Transdermal delivery of hyaluronan tetrasaccharide by constant current iontophoresis,
    International Journal of Pharmaceutical Sciences Research, 3, 113, 2016.
  • Masayoshi Miyamoto, Yuji Yamashita, Yoshihiro Tokudome*,
    Novel Bicontinuous Alpha-Gel Formation with Amphiphilic Tranexamic Acid Derivative and Its Application to Cosmetics,
    Oleo Science, 16, 337, 2016.
  • 森 俊裕, 徳留 嘉寛,
    皮脂分泌抑制剤,
    特許公開2016-150916
  • 徳留 嘉寛、土黒 一郎、森 紗也香,
    メラニン産生抑制剤,
    再表2016/121962
  • 田嶋 和夫, 今井 洋子, 山下 和也, 本間 明日香, 山口 みずほ, 高垣欣也, 徳留 嘉寛,
    皮膚外用剤および皮膚バリア機能改善剤,
    特許公開2016-084340

2015年

  • Yoshihiro Tokudome*, Mishina Katayanagi, Fumie Hashimoto,
    Evaluation of esterase activity in reconstructed human epidermal cultured skin model and its intracellular localization,
    Annals of Dermatology, 27, 269- 274, 2015
  • Kazuyuki Kitazawa, Satoshi Kano, Fumie Hashimoto, Kenji Sugibayashi, Yoshihiro Tokudome*,
    Chondroitin sulfate disaccharide enhances extracellular matrix-related gene and protein expression in normal human dermal fibroblasts in vitro,
    Journal of Japanese Cosmetic Science Society, 39, 1-6, 2015.
  • Mami Yokota, Yoshihiro Tokudome*,
    Permeation of hydrophilic molecules across glycated skin is differentially regulated by the stratum corneum and epidermis-dermis,
    Biological & Pharmaceutical Bulletin, 38, 1383-1388, 2015.
  • Yoshihiro Tokudome*, Kaoru Nakamura, Yurina Itaya, Fumie Hashimoto,
    Enhancement of skin penetration of hydrophilic and lipophilic compounds by pH-sensitive liposomes,
    Journal of Pharmacy and Pharmaceutical Sciences, 18, 249-257, 2015.
  • Koji Nomoto, Fumie Hashimoto, Kenji Sugibayashi, Yoshihiro Tokudome*,
    Increasing effect of ceramides in skin by topical application of sphingosine,
    Global Dermatology, 2, 154-158, 2015.
  • Yutaka Inoue , Kengo Suzuki, Toshinari Ezawa, Isamu Murata, Mami Yokota, Yoshihiro Tokudome, Ikuo Kanamoto,
    Examination of the physicochemical properties of caffeic acid complexed with γ-cyclodextrin,
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 83, 289-298, 2015.
  • 徳留嘉寛,
    トロポエラスチン発現促進剤およびエラスチン産生促進剤,
    特許公開2015-178493
  • 徳留嘉寛,
    化粧料,
    特許公開2015-166330

2014年

  • Yoshihiro Tokudome*, Mamiko Endo, Fumie Hashimoto,
    Application of glucosylceramide based liposomes increased the ceramide content in a three-dimensional cultured skin epidermis,
    Skin Pharmacology and Physiology, 27, 18-24, 2014.
  • Madoka Kage, Yoshihiro Tokudome*, Yukiko Matsunaga, Takeshi Hariya, Fumie Hashimoto,
    Effect of hyaluronan tetrasaccharides on epidermal differentiation in normal human epidermal keratinocytes,
    International Journal of Cosmetic Science, 36, 109-115, 2014.
  • Masaki Okawara, Yoshihiro Tokudome, Hiroaki Todo, Kenji Sugibayashi, Fumie Hashimoto,
    Effect of β-cyclodextrin derivatives on the diosgenin absorption in Caco-2 cell monolayer and rats,
    Biological & Pharmaceutical Bulletin, 37, 54-59, 2014.
  • Yoshihiro Tokudome*, Kyosuke Nakamura, Fumie Hashimoto,
    Effects of low molecular weight soybean peptide on mRNA and protein expression levels of differentiation markers in normal human epidermal keratinocytes,
    Bioscience, Biotechnology, and Biochemistry, 78, 1018-1021, 2014.
  • Masaki Okawara, Fumie Hashimoto, Hiroaki Todo, Kenji Sugibayashi, Yoshihiro Tokudome*,
    Effect of liquid crystals with cyclodextrin on the bioavailability of a poorly water-soluble compound, diosgenin, after its oral administration to rats,
    International Journal of Pharmaceutics, 472, 257-261, 2014
  • 土黒一郎,森紗也香,田能村昌久,徳留嘉寛,
    チロシナーゼ活性阻害剤及び美白剤,
    WO2014/092166
  • 小山義之,徳留嘉寛,鈴木保博,
    ヒアルロナンを含むナノ粒子,
    特開2014-91708
  • 徳留嘉寛,
    イオントフォレーシス用組成物,
    特開2014-80374

2013年

  • Madoka Kage, Yoshihiro Tokudome, Fumie Hashimoto,
    Permeation of hyaluronan tetrasaccharides through hairless mouse skin: an in vitro and in vivo study
    Archives of Dermatological Research, 305, 69-77, 2013.
  • Masaki Okawara, Yoshihiro Tokudome, Hiroaki Todo, Kenji Sugibayashi, Fumie Hashimoto,
    Enhancement of Diosgenin distribution in the skin by cyclodextrin complexation following oral administration
    Biological & Pharmaceutical Bulletin, 36, 36-40, 2013.
  • Madoka Kage, Yoshihiro Tokudome, Yukiko Matsunaga, Takeshi Hariya, Fumie Hashimoto,
    Expression of hyaluronan synthase and collagen type I mRNA by hyaluronan tetrasaccharides in normal human dermal fibroblasts,
    Journal of Japanese Cosmetic Science Society, 37, 1-5, 2013.
  • Makoto Otsuka, Yoshihiro Tokudome, Kuniko Otsuka, Atsuo Ito,
    Therapeutic effect of lipophilic and/or hydrophilic zinc related compound injections on alveolar bone mass in zinc-deficient osteoporosis rats,
    Key Engineering Materials, Vols. 529-530, 457-460 2013
  • Tomoko Ito, Racquel, Z. LeGeros, Manami Takemasa, Yoshihiro Tokudome, Tomohiro Uchino, Atsuo Ito, Makoto Otsuka, Effect of calcium phosphate compound (MZF-CaP) with and without fluoride in preventing bone loss in ovariectomized rats, International Journal of Drug Delivery, 5, 412-419, 2013
  •  徳留嘉寛,
    スフィンゴ糖脂質水溶液若しくは乳化水溶液,
    特開2013-155117

2012年

  • Yoshihiro Tokudome *, Kyosuke Nakamura, Madoka Kage, Hiroaki Todo, Kenji Sugibayashi, Fumie Hashimoto,
    Effects of soybean peptide and collagen peptide on collagen synthesis in normal human dermal fibroblasts,
    International Journal of Food Sciences and Nutrition, 63, 689-695, 2012.
  • Yoshihiro Tokudome *, Madoka Kage, Fumie Hashimoto,
    Influence of oral administration of soybean peptide on water content of stratum corneum, transepidermal water loss and skin viscoelasticity,
    Journal of Nutrition and Food Sciences, 2, 137, 2012.
  • Yoshihiro Tokudome, Makoto Otsuka,
    Possibility of alveolar bone promoting enhancement by using lipophilic and/or hydrophilic zinc related compounds in zinc-deficient osteoporosis rats,
    Biological & Pharmaceutical Bulletin, 35, 1496-1501, 2012.
  • Yukiko Matsunaga, Shigeyoshi Fujiwara, Yuichiro Mori, Akiko Miyake, Haruyo Yamanishi, Madoka Kage, Yoshihiro Tokudome, Fumie Hashimoto, Takeshi Hariya,
    Development of self-dissolving microneedles consisting hyaluronic acid as an anti-wrinkle treatment
    IFSCC Magazine, 15, 73-78, 2012
  • 徳留嘉寛,橋本フミ惠,岡安武蔵,
    内因性セラミドの生成・増加方法,
    特開2012-184166
  • 杉林堅次,橋本フミ惠,徳留嘉寛,金辰彦,
    セラミド合成促進剤、化粧料、皮膚外用剤、医薬部外品、医薬品およびセラミド合成促進剤の製造方法,
    特開2012-25720

2011年

  • Keisuke Yamada, Jun Yamashita, Hiroaki Todo, Keiko Miyamoto, Satoru Hashimoto, Yoshihiro Tokudome, Fumie Hashimoto, Kenji Sugibayashi,
    Preparation and evaluation of liquid-crystal formulations with skin- permeation- enhancing abilities for entrapped drugs,
    Journal of Oleo Science, 60, 31-40, 2011
  • Yoshihiro Tokudome *, Miyuki Jinno, Hiroaki Todo, Tatsuhiko Kon, Kenji Sugibayashi, Fumie Hashimoto,
    Increase in ceramide level after application of various sizes of sphingomyelin liposomes to cultured human skin model
    Skin Pharmacology and Physiology, 24, 218-223, 2011
  • Yoshihiro Tokudome, Atsuo Ito, Makoto Otsuka,
    Effect of Zinc-containing β-tricalcium phosphate nano particles injection on jawbone mineral density and mechanical strength of osteoporosis model rats
    Biological & Pharmaceutical Bulletin, 34, 1215-1218, 2011
  • Satoshi Kano, Hiroaki Todo, Katsunori Furui, Kenichi Sugie, Yoshihiro Tokudome, Fumie Hashimoto, Hajime Kojima, Kenji Sugibayashi,
    Comparison of several reconstructed cultured human skin models by microscopic Observation: Their Usefulness as an Alternative Membrane for Skin in Drug Permeation Experiments,
    Alternatives to Animal Testing and Experimentation, 16, 51-58, 2011.
  • 杉林堅次,徳留嘉寛,金辰彦,
    セメラニン合成促進物質の製造方法、メラニン合成促進物質、皮膚外用剤、チロシナーゼ活性物質の製造方法、チロシナーゼ活性物質、および医薬品,
    特開2011-136976

2010年

  • Yoshihiro Tokudome *, Raina Uchida, Takeshi Yokote, Hiroaki Todo, Nobuko Hada, Tatsuhiko Kon, Junko Yasuda, Hidenori Hayashi, Fumie Hashimoto, Kenji Sugibayashi,
    Effect of topically applied sphingomyelin-based liposomes on the ceramide level in a three-dimensional cultured human skin model,
    Journal of Liposome Research, 20, 49-54, 2010.
  • Masaki Okawara, Yoshihiro Tokudome, Hiroaki Todo, Kenji Sugibayashi, Fumie Hashimoto,
    Diosgenin disposition in rats after i.v. and p.o. administration,
    Journal of Pharmaceutical Science Technology Japan, 70, 82-86, 2010.
  • Yasuko Obata, Shunichi Utsumi, Hiroshi Watanabe, Masafumi Suda, Yoshihiro Tokudome, Makoto Otsuka, Kozo Takayama,
    Infrared spectroscopic study of lipid interaction in stratum corneum treated with transdermal absorption enhancers,
    International Journal of Pharmaceutics, 389, 18-23, 2010.
  • Naoko Inoue, Hiroaki Todo, Dai Iidaka, Yoshihiro Tokudome, Fumie Hashimoto, Tohru Kishino, Kenji Sugibayashi,
    Possibility and effectiveness of drug delivery to skin by needle-free injector,
    International Journal of Pharmaceutics, 391, 65-72, 2010.
  • Hiroaki Todo, Eriko Kimura, Hirotaka Yasuno, Yoshihiro Tokudome, Fumie Hashimoto, Yoshiaki Ikarashi, Kenji Sugibayashi,
    Permeation pathway of macromolecules and nanospheres through skin,
    Biological & Pharmaceutical Bulletin, 33, 1394-1399, 2010.
  • Satoshi Kano, Hiroaki Todo, Kenichi Sugie, Hidenori Fujimoto, Keiichi Nakada, Yoshihiro Tokudome, Fumie Hashimoto, Kenji Sugibayashi,
    Utilization of reconstructed cultured human skin models as an alternative skin for permeation studies of chemical compounds,
    Alternatives to Animal Testing and Experimentation, 15, 61-70, 2010.

2009年

  • Yoshihiro Tokudome *, Yuko Saito, Fumihiko Sato, Maki Kikuchi, Toshihiro Hinokitani, Kenichi Goto,
    Preparation and characterization of ceramide-based liposomes with high fusion activity and high membrane fluidity,
    Colloids and Surfaces, B: Biointerfaces, 73, 92-96, 2009.
  • Makoto Otsuka, Koyuki Ibe, Yoshihiro Tokudome, Hiroyuki Ohshima,
    Nano- and macro-geometrical structural change of caffeine and theophylline anhydrate tablets during hydration process by using X-ray computed tomography,
    Colloids and Surfaces, B: Biointerfaces, 73, 351-359, 2009.
  • Mariko Koike, Toshihiko Kitamura, Hiroaki Todo, Yoshihiro Tokudome,Fumie Hashimoto, Yasunori Isshiki, Seiichi Kondo, Kenji Sugibayashi,
    Bactericidal activities of several electrolyzed waters,
    Journal of Society of Cosmetic Chemists of Japan, 43, 101-106, 2009.
  • Atsuo Ito, Yu Sogo, Yoshihiro Tokudome, Makoto Otsuka, Yasutaka Yamada, Hirotaka Mutsuzaki, Masataka Sakane,
    Trace metal-substituted tricalsium phosphates having pharmacological effects,
    Journal of Japanese Society for Biomaterials (in Japanese), 27, 84-89, 2009.
  • 大塚誠,徳留嘉寛,
    細胞分裂促進活性化剤,
    特開2009-161500
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