Gerardさんが第78回FIP会議にて優秀発表者賞を受賞を受賞しました。

Iontophoresis-assisted delivery of pilocarpine to the eyeball through eyelid skin
Gerard Lee L. See*, Ayano Sagesaka, Hazuki Torizuka, Hiroaki Todo, Kenji Sugibayashi
My preferred method of presentation is: Oral Presentation
Background: Eyelid skin, the thinnest skin layer in the body, has attracted attention as a drug delivery site for ophthalmic drugs as an alternative to conventional eye drops. Previously, it was found that the concentration of drugs in the conjunctival sac administered via eyelid skin is lower than eye drop administration. In this case, we considered the necessity to utilize physical approaches, such as iontophoresis (IP), to promote percutaneous absorption of drugs delivered to the eyeball via the lower eyelid skin. Pilocarpine, a hydrophilic drug used to treat glaucoma, was selected as a model drug.
Purpose: We investigated the usefulness of iontophoresis on pilocarpine permeability through lower eyelid skin of hairless rats.
Methods: In vitro diffusion cells were used to assess skin permeability in order to provide key insights into the relationship between skin type and drug. Moreover,in vivo skin permeation was conducted to determine drug distribution in the eyeball. For IP, the applied current was set at 0.3 mA/cm2. Samples were analyzed using HPLC and LCMS-MS.
Results: Seven-fold higher permeation via eyelid skin was observed, indicating a significant permeation enhancement attributed to the presence of IP application. In addition, significant differences were observed in the eyeball concentrations between the presence of IP and absence of IP at 30 minutes (p<0.05) post administration of pilocarpine. Conclusion: From these data, it is suggested that application of IP in a short time is effective for drug delivery to eyeballs.